Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Imidazole ketone erastin (IKE) (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
2 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 212.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 497.00 | |
50 mg | In stock | $ 723.00 | |
100 mg | In stock | $ 987.00 | |
500 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 192.00 |
Description | Imidazole ketone erastin (IKE) (IKE) is an inducer of ferroptosis. It has inhibition of the system Xc- cystine/glutamate transporter. |
In vitro | Human astrocytoma cells (CCF-STTG1) were used, which contain the system xc?.17 Following a 2 h incubation period, glutamate released into the medium was detected fluorometrically using glutamate oxidase, horseradish peroxidase, and Amplex UltraRed. Dramatic improvement of the half-maximal inhibitory constants (IC50) for system xc? inhibition was observed for IKE (IC50: 30 nM), compared to erastin and PE [1]. |
In vivo | In a diffuse large B cell lymphoma (DLBCL) xenograft model, IKE exerted an antitumor effect by inhibiting system xc-, leading to glutathione depletion, lipid peroxidation, and the induction of ferroptosis biomarkers [2]. |
Synonyms | IKE |
Molecular Weight | 655.14 |
Formula | C35H35ClN6O5 |
CAS No. | 1801530-11-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (152.64 mM)
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Imidazole ketone erastin 1801530-11-9 Apoptosis Ferroptosis IKE inhibitor inhibit