Powder: -20°C for 3 years | In solvent: -80°C for 1 year
I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 70.00 | |
5 mg | In stock | $ 172.00 | |
10 mg | In stock | $ 272.00 | |
25 mg | In stock | $ 547.00 | |
50 mg | In stock | $ 789.00 | |
100 mg | In stock | $ 1,080.00 | |
500 mg | In stock | $ 2,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 185.00 |
Description | I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST. |
Targets&IC50 | Hippo pathway:2.7 μM |
In vitro | I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2]. |
Synonyms | HMPSNE |
Molecular Weight | 310.37 |
Formula | C17H14N2O2S |
CAS No. | 459420-09-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120mg/mL (386.64mM)
You can also refer to dose conversion for different animals. More
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I3MT-3 459420-09-8 Stem Cells Hippo pathway EA.hy926 cells Hippo (MST) inhibit 3MST HEK293 I3MT3 cell-membrane HMPSNE COS-7 I-3MT-3 I3MT 3 Inhibitor inhibitor