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I3MT-3

Catalog No. T8851   CAS 459420-09-8
Synonyms: HMPSNE

I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.

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I3MT-3 Chemical Structure
I3MT-3, CAS 459420-09-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 70.00
5 mg In stock $ 172.00
10 mg In stock $ 272.00
25 mg In stock $ 547.00
50 mg In stock $ 789.00
100 mg In stock $ 1,080.00
500 mg In stock $ 2,190.00
1 mL * 10 mM (in DMSO) In stock $ 185.00
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Purity: 99.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST.
Targets&IC50 Hippo pathway:2.7 μM
In vitro I3MT-3 shows a dose-dependent inhibition of 3-MST activity from CT26 homogenates, which contain the murine form of the enzyme. The IC50 of HMPSNE for murine 3-MST is calculated as 2.3 μM with a cozncentration-dependent decrease of AzMC fluorescence[1].I3MT-3 (0-300 μM; 48 hours) inhibits CT26 cells proliferate with increasing concentrations of I3MT-3. Confluence of cells treated with HMPSNE is recorded each hour for 48 h by the IncuCyte method[2].
Synonyms HMPSNE
Molecular Weight 310.37
Formula C17H14N2O2S
CAS No. 459420-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120mg/mL (386.64mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Hanaoka K, Sasakura K, Suwanai Y, et al. Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 2017;7:40227. Published 2017 Jan 12. doi:10.1038/srep40227

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Covalent Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Kinase Inhibitor Library Inhibitor Library Anti-Prostate Cancer Compound Library Stem Cell Differentiation Compound Library Bioactive Compounds Library Max

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XMU-MP-1 Cerdulatinib hydrochloride IHMT-MST1-58 Pim1/AKK1-IN-1

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Keywords

I3MT-3 459420-09-8 Stem Cells Hippo pathway EA.hy926 cells Hippo (MST) inhibit 3MST HEK293 I3MT3 cell-membrane HMPSNE COS-7 I-3MT-3 I3MT 3 Inhibitor inhibitor

 

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