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Halobetasol propionate

Catalog No. T6529 CAS 66852-54-8

Synonyms: Halobetasol Propionate, Ulobetasol propionate, BMY-30056, CGP-14458

Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.

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Halobetasol propionate Chemical Structure

Halobetasol propionate, CAS 66852-54-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 40.00
25 mg	In stock	$ 59.00
50 mg	In stock	$ 74.00
100 mg	In stock	$ 116.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

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Purity: 99.85%

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Description

In vitro

Halobetasol propionate is thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The initial interaction, however, is due to the drug binding to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes.[1]

Synonyms	Halobetasol Propionate, Ulobetasol propionate, BMY-30056, CGP-14458
Molecular Weight	484.96
Formula	C25H31ClF2O5
CAS No.	66852-54-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 36 mg/mL (74.2 mM)

DMSO: 90 mg/mL (185.6 mM)

References and Literature

1. Mohandas S, et al. Indian J Dermatol Venereol Leprol, 2009, 75(2), 186-187.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compound Library Target-Focused Phenotypic Screening Library NO PAINS Compound Library Anti-Obesity Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Anti-Fibrosis Compound Library FDA-Approved Drug Library

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Keywords

Halobetasol propionate 66852-54-8 Metabolism Phospholipase Inhibitor BMY30056 BMY 30056 Ulobetasol Propionate Halobetasol Propionate Halobetasol (propionate) CGP14458 inhibit Ulobetasol propionate CGP 14458 BMY-30056 CGP-14458 inhibitor

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