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Golotimod (TFA) (229305-39-9 free base)

Catalog No. T11449L2 CAS T11449L2

Synonyms: SCV 07 (TFA), Gamma-D-glutamyl-L-tryptophan (TFA), Golotimod (TFA)

Golotimod TFA (SCV 07 TFA) is an immunomodulatory peptide with antibacterial properties that significantly increases the effectiveness of anti-tuberculosis studies, stimulates thymus and splenocyte proliferation and improves macrophage function. Golotimod TFA has the potential to be used in studies of recurrent genital herpes simplex virus type 2 (HSV-2).

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Golotimod (TFA) (229305-39-9 free base) Chemical Structure

Golotimod (TFA) (229305-39-9 free base), CAS T11449L2

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Biological Description

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Storage & Solubility Information

Description	Golotimod TFA (SCV 07 TFA) is an immunomodulatory peptide with antibacterial properties that significantly increases the effectiveness of anti-tuberculosis studies, stimulates thymus and splenocyte proliferation and improves macrophage function. Golotimod TFA has the potential to be used in studies of recurrent genital herpes simplex virus type 2 (HSV-2).
In vitro	Golotimod is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) [1]. Golotimod inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin [2].

Synonyms	SCV 07 (TFA), Gamma-D-glutamyl-L-tryptophan (TFA), Golotimod (TFA)
Molecular Weight	447.36
Formula	C18H20F3N3O7
CAS No.	T11449L2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6. 2. Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92. 3. Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60.

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Keywords

Golotimod (TFA) (229305-39-9 free base) T11449L2 JAK/STAT signaling Stem Cells STAT SCV07 SCV-07 Golotimod (TFA) (229305399 free base) SCV 07 Golotimod (TFA) (229305 39 9 free base) SCV 07 (TFA) 229305-39-9 Gamma-D-glutamyl-L-tryptophan Gamma-D-glutamyl-L-tryptophan (TFA) 229305-39-9 free base Golotimod Golotimod (TFA) inhibitor inhibit

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