store under nitrogen,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,530.00 | |
50 mg | 8-10 weeks | $ 1,990.00 | |
100 mg | 8-10 weeks | $ 3,150.00 |
Description | GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain. |
Targets&IC50 | TAF12:10 nM |
In vitro | GNE-371 (Compound 27) binds to TAF1(2) with an IC50 of 10 nM, while maintaining excellent selectivity over other bromodomain-family members. GNE-371 also exhibits activity in a cellular TAF1(2) target-engagement assay (IC50 = 38 nM) and shows synergistic antiproliferative effects with the BET inhibitor JQ1[1]. |
Molecular Weight | 431.49 |
Formula | C24H25N5O3 |
CAS No. | 1926986-36-8 |
store under nitrogen,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (69.53 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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GNE-371 1926986-36-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis GNE371 GNE 371 inhibitor inhibit