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Fmoc-aminooxy-PEG12-NHS ester

Catalog No. T17948 CAS T17948

Fmoc-aminooxy-PEG12-NHS ester is a polyethylene glycol (PEG) derivative commonly employed as a PROTAC linker for the synthesis of PROTACs[1].

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Fmoc-aminooxy-PEG12-NHS ester, CAS T17948

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fmoc-aminooxy-PEG12-NHS ester is a polyethylene glycol (PEG) derivative commonly employed as a PROTAC linker for the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight	953.03
Formula	C46H68N2O19
CAS No.	T17948

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fmoc-aminooxy-PEG12-NHS ester T17948 Others Fmoc aminooxy PEG12 NHS ester Fmoc-aminooxy-PEG-12-NHS ester FmocaminooxyPEG12NHS ester inhibitor inhibit

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