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Catalog No. T12621L   CAS 1959551-26-8

FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).

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FT671 Chemical Structure
FT671, CAS 1959551-26-8
Pack Size Availability Price/USD Quantity
25 mg 8-10 weeks $ 2,120.00
50 mg 8-10 weeks $ 2,780.00
100 mg 8-10 weeks $ 3,700.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
Targets&IC50 USP7:52 nM
In vitro FT671 promotes the degradation of N-Myc and enhances p53 levels in the neuroblastoma cell line IMR-32, as well as in HCT116 and bone osteosarcoma (U2OS) cell lines. This results in the activation of p53 target genes, including BBC3 (which encodes PUMA), CDKN1A (p21), RPS27L (S27L), and MDM2. Additionally, in the MM.1S multiple myeloma cell line, FT671 stabilizes p53, associated with an upsurge in MDM2 ubiquitination. This stabilization of p53 triggers the expression of its target genes.
In vivo FT671 is well-to related even at high doses. FT671 (100 mg/kg and 200 mg/kg, oral gavage, daily) treatment in mice causes an obviously dose-dependent inhibition of tumor growth.
Molecular Weight 533.48
Formula C24H23F4N7O3
CAS No. 1959551-26-8


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (93.72 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017 Oct 26;550(7677):481-486.


1. Xu X, Zhang S, Wang Y, et al. Virtual Screening Inhibitors of Ubiquitin-specific Protease 7 combining Pharmacophore Modeling and Molecular Docking. Molecular Informatics. 2022 2. Li H, Sun Y, Yin H, et al.Virtual screening of natural products targeting ubiquitin-specific protease 7.Journal of Biomolecular Structure and Dynamics.2024: 1-8.

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USP28-IN-3 IU1-248 USP28-IN-4 C527 USP7-IN-8 DUB-IN-2 HBX 19818 OTUB1/USP8-IN-1 HCl

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FT671 1959551-26-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB FT 671 FT-671 inhibitor inhibit