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FR 167653

Catalog No. T11327 CAS 158876-66-5

Synonyms: FR 167653 sulfate

FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.

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FR 167653, CAS 158876-66-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.
In vivo	FR 167653 (32 mg/kg;?i.h.;?24-48 hours) significantly decreases the extent of acute tubular necrosis.

Synonyms	FR 167653 sulfate
Molecular Weight	525.51
Formula	C24H20FN5O6S
CAS No.	158876-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407. 2. Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67. 3. Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74.

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Keywords

FR 167653 158876-66-5 MAPK p38 MAPK FR-167653 FR167653 FR 167653 Sulfate FR-167653 Sulfate FR167653 Sulfate FR 167653 sulfate inhibitor inhibit

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