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Etarotene

Catalog No. T25393 CAS 87719-32-2

Synonyms: RO15-1570, Arotinoid ethyl sulphone, RO-15-1570, RO 15-1570

Etarotene (Arotinoid ethyl sulphone) is an ethylsulfonyl derivative of aloe acid with differentiation-inducing and potentially antitumor activity.Etarotene is a collagenase inhibitor and can be used to study psoriasis.

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Etarotene, CAS 87719-32-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 258.00
5 mg	In stock	$ 642.00
10 mg	In stock	$ 913.00
25 mg	In stock	$ 1,370.00
50 mg	In stock	$ 1,850.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 100%

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Description	Etarotene (Arotinoid ethyl sulphone) is an ethylsulfonyl derivative of aloe acid with differentiation-inducing and potentially antitumor activity.Etarotene is a collagenase inhibitor and can be used to study psoriasis.
In vivo	Ro 15-1570 (6 mg/kg; oral; 1 and 2 weeks; rats) show weight loss, alopecia, erythema, desquamation of the skin, and alterations of the skeletal system. The present demonstration that the arotinoid ethyl sulfone Ro 15-1570 was devoid of bone toxicity constitutes major progress in the pharmacologic development of retinoids with a better balance between therapeutic and adverse effects.[5]

Synonyms	RO15-1570, Arotinoid ethyl sulphone, RO-15-1570, RO 15-1570
Molecular Weight	396.59
Formula	C25H32O2S
CAS No.	87719-32-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zheng ZS, et al. Regulation of the induction of ornithine decarboxylase in keratinocytes by retinoids. Biochem J. 1995 Jul 1;309 ( Pt 1):159-65. 2. Xue GZ, et al. Phorbol 12-myristate 13-acetate inhibits epidermal growth factor signalling in human keratinocytes, leading to decreased ornithine decarboxylase activity. Biochem J. 1996 Oct 15;319 ( Pt 2):641-8. 3. Wyss R, et al. Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching. III. Determination of the arotinoid sumarotene and its Z-isomer in human and animal plasma. J Chromatogr. 1992 Apr 15;576(1):111-20. 4. Kistler A, et al. Comparative teratogenicity of three retinoids: the arotinoids Ro 13-7410, Ro 13-6298 and Ro 15-1570. Arch Toxicol. 1990;64(1):43-48. 5. Kistler A, et al. Ro 15-1570, a new sulfur-containing retinoid devoid of bone toxicity in rats. Arch Toxicol. 1984;56(2):117-122.

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Keywords

Etarotene 87719-32-2 Proteases/Proteasome Tyrosinase RO15-1570 Arotinoid ethyl sulphone RO-15-1570 RO 15-1570 inhibitor inhibit

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