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EP1013

Catalog No. T11210 CAS 223568-55-6

Synonyms: F1013

EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.

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EP1013, CAS 223568-55-6

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 759.00
50 mg	8-10 weeks	$ 986.00
100 mg	8-10 weeks	$ 1,590.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.

In vivo

EP1013 therapy significantly improves the functionality and longevity of syngeneic islet grafts by enhancing the islet mass's performance. Administering EP1013 at dosages of 1, 3, and 10 mg/kg results in noticeable improvements in the function of marginal islet mass. Despite two cases of primary islet graft nonfunction in the 10 mg/kg EP1013 treatment group, the overall rate of diabetes reversal among this group does not significantly differ from those treated with 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD.

Synonyms	F1013
Molecular Weight	382.38
Formula	C18H23FN2O6
CAS No.	223568-55-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (156.91 mM)

References and Literature

1. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EP1013 223568-55-6 Apoptosis Proteases/Proteasome Caspase F1013 F-1013 EP 1013 F 1013 EP-1013 inhibitor inhibit

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