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ELN318463 racemate

Catalog No. T11178L CAS 851599-82-1

Synonyms: ELN318463 (racemate), ELN 318463 racemate

ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

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ELN318463 racemate, CAS 851599-82-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 276.00
5 mg	In stock	$ 688.00
10 mg	In stock	$ 1,080.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 2,170.00
100 mg	In stock	$ 2,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 786.00

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Purity: 99.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
In vitro	ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656 nM for PS1and PS2, respectively[1].
In vivo	Brain levels of ELN318463 (30 mg/kg) are 0.754 μM in FVB brains and 0.69 μM, and of ELN318463(100 mg/kg) are 2.7 μM in FVB brains and 1.87 μM in PDAPP brains[1].

Synonyms	ELN318463 (racemate), ELN 318463 racemate
Molecular Weight	471.8
Formula	C19H20BrClN2O3S
CAS No.	851599-82-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (105.98 mM)

References and Literature

1. Zhao B, et al. Identification of gamma-secretase inhibitor potency determinants on presenilin. J Biol Chem. 2008 Feb 1;283(5):2927-38. 2. Basi GS, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther. 2010 Dec 29;2(6):36.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Inhibitor Library Bioactive Compound Library ReFRAME Related Library Bioactive Compounds Library Max Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

BMS 299897 E 2012 γ-Secretase-IN-1 Avagacestat Crenigacestat 3,5-Bis(4-nitrophenoxy)benzoic acid IMR-1A Jagged-1 (188-204) TFA(219127-21-6 free base)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ELN318463 racemate 851599-82-1 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase ELN318463 ELN 318463 ELN318463 (racemate) racemate ELN-318463 ELN 318463 racemate inhibitor inhibit

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