keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 95.00 | |
5 mg | In stock | $ 356.00 | |
10 mg | In stock | $ 533.00 | |
25 mg | In stock | $ 863.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,580.00 |
Description | ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide. |
Targets&IC50 | Gαi1:8.6 nM(EC50), β-arrestin2:166 nM(EC50) |
In vitro | ELA-14 activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. ELA-14 induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1]. |
In vivo | ELA-14 is rapidly metabolized in rat plasma (t1/2<2 min)[1]. |
Synonyms | ELA-14(human) acetate (1886973-05-2 free base) |
Molecular Weight | 1767.09 |
Formula | C77H123N25O19S2 |
CAS No. | TP1923L1 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/ml (56.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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ELA-14(human) acetate TP1923L1 GPCR/G Protein Apelin receptor Arrestin ELA 14(human) acetate ELA-14(human) acetate (1886973-05-2 free base) 1886973-05-2 ELA14 Acetate ELA 14 Acetate 1886973-05-2 free base ELA-14 Acetate ELA14(human) acetate inhibitor inhibit