Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

DAPTA

DAPTA
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
Catalog No. T7624Cas No. 106362-34-9
Select Batch
Purity:100%
Contact us for more batch information
Resource Download

DAPTA

Catalog No. T7624Cas No. 106362-34-9
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$47In Stock
5 mg$89In Stock
10 mg$155In Stock
25 mg$297In Stock
50 mg$443In Stock
100 mg$639In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "DAPTA"

Product Introduction

Bioactivity
Description
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
Targets&IC50
Gp120 BaL/sCD4-CCR5:55 pM (IC50, in Cf2Th/synR5 cells), Gp120CM CM235/sCD4-CCR5:0.32 nM (IC50, in Cf2Th/synR5 cells)
In vitro
D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by > 90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1]
AliasDAPTA(TFA), D-Ala-peptide T-amide, Adaptavir
Chemical Properties
Molecular Weight856.88
FormulaC35H56N10O15
Cas No.106362-34-9
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1670 mL5.8351 mL11.6702 mL58.3512 mL
5 mM0.2334 mL1.1670 mL2.3340 mL11.6702 mL
10 mM0.1167 mL0.5835 mL1.1670 mL5.8351 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy DAPTA | purchase DAPTA | DAPTA cost | order DAPTA | DAPTA chemical structure | DAPTA in vitro | DAPTA formula | DAPTA molecular weight