DAPTA

DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.

Catalog No. T7624Cas No. 106362-34-9

Select Batch

Purity:100%

Resource Download

COA LCMS HNMR

DAPTA

Catalog No. T7624Cas No. 106362-34-9

DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$89	In Stock
10 mg	$155	In Stock
25 mg	$297	In Stock
50 mg	$443	In Stock
100 mg	$639	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "DAPTA"

Product Introduction

Bioactivity

Description	DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.
Targets&IC50	Gp120 BaL/sCD4-CCR5:55 pM (IC50, in Cf2Th/synR5 cells), Gp120CM CM235/sCD4-CCR5:0.32 nM (IC50, in Cf2Th/synR5 cells)
In vitro	D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by > 90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1]
Alias	DAPTA(TFA), D-Ala-peptide T-amide, Adaptavir

Chemical Properties

Molecular Weight	856.88
Formula	C₃₅H₅₆N₁₀O₁₅
Cas No.	106362-34-9

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 10 mM

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1670 mL	5.8351 mL	11.6702 mL	58.3512 mL
5 mM	0.2334 mL	1.1670 mL	2.3340 mL	11.6702 mL
10 mM	0.1167 mL	0.5835 mL	1.1670 mL	5.8351 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc