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D2343

Catalog No. T15042 CAS 72734-63-5

D2343 is an agonist of β2-adrenoceptor. It also is an inhibitor of α1- adrenoceptor.

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D2343, CAS 72734-63-5

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 970.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	D2343 is an agonist of β2-adrenoceptor. It also is an inhibitor of α1- adrenoceptor.
In vitro	D2343 shows in addition an alpha 1-receptor inhibitory activity [1]. The beta 2-agonistic and alpha 1-antagonistic drug D2343 inhibits the evoked contractions in a concentration related fashion with 50% effect at 9.6 μM [2].
In vivo	D2343 has shown an ability to relax the uterine muscles to the same degree as Terbutaline or even more, especially when the two drugs are compared in preparations from rabbit and rat. D2343 has been compared to the beta 2-agonist Terbutaline on oestrogenized uterine preparations from rat and in myometrial strips from homo and rabbit [1].

Molecular Weight	329.43
Formula	C20H27NO3
CAS No.	72734-63-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Olsson OA, et al. The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):391-7. 2. Olsson OA, et al. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol (Copenh). 1985 May;56(5):427-30.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

D2343 72734-63-5 GPCR/G Protein Neuroscience Adrenergic Receptor D-2343 Inhibitor inhibitor inhibit

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