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D2343

Catalog No. T15042   CAS 72734-63-5

D2343 is an agonist of β2-adrenoceptor. It also is an inhibitor of α1- adrenoceptor.

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D2343, CAS 72734-63-5
Pack Size Availability Price/USD Quantity
5 mg 8-10 weeks $ 970.00
50 mg 8-10 weeks $ 1,980.00
100 mg 8-10 weeks $ 2,500.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description D2343 is an agonist of β2-adrenoceptor. It also is an inhibitor of α1- adrenoceptor.
In vitro D2343 shows in addition an alpha 1-receptor inhibitory activity [1]. The beta 2-agonistic and alpha 1-antagonistic drug D2343 inhibits the evoked contractions in a concentration related fashion with 50% effect at 9.6 μM [2].
In vivo D2343 has shown an ability to relax the uterine muscles to the same degree as Terbutaline or even more, especially when the two drugs are compared in preparations from rabbit and rat. D2343 has been compared to the beta 2-agonist Terbutaline on oestrogenized uterine preparations from rat and in myometrial strips from homo and rabbit [1].
Molecular Weight 329.43
Formula C20H27NO3
CAS No. 72734-63-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Olsson OA, et al. The effects in myometrial preparations of D2343, a beta 2-adrenoceptor agonist possessing alpha 1-receptor blocking qualities. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):391-7. 2. Olsson OA, et al. The effect of D2343 in transmurally stimulated rabbit isthmus muscle. Acta Pharmacol Toxicol (Copenh). 1985 May;56(5):427-30.

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Keywords

D2343 72734-63-5 GPCR/G Protein Neuroscience Adrenergic Receptor D-2343 Inhibitor inhibitor inhibit