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Ceruletide

Name: Ceruletide
Brand: TargetMol
SKU: T14932
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14932Cas No. 17650-98-5

Alias FI-6934, Cerulein, Caerulein

Ceruletide is a decapeptide that serves as a safe and effective cholecystokinin receptor agonist, exerting a direct spasmogenic effect on the gallbladder muscle and bile ducts, and is commonly used to establish pancreatitis models.

Ceruletide

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Purity: 98.47%

Catalog No. T14932Alias FI-6934, Cerulein, CaeruleinCas No. 17650-98-5

Pack Size	Price	USA Warehouse	Global Warehouse
100 μg	$31	In Stock	In Stock
500 μg	$56	In Stock	In Stock
1 mg	$89	In Stock	-
5 mg	$347	In Stock	-
10 mg	$538	In Stock	-
25 mg	$856	In Stock	-
50 mg	$1,150	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.47%

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COA HPLC MS HPLC MS

Product Introduction

Bioactivity

Description	Ceruletide is a decapeptide that serves as a safe and effective cholecystokinin receptor agonist, exerting a direct spasmogenic effect on the gallbladder muscle and bile ducts, and is commonly used to establish pancreatitis models.
Targets&IC50	mice:1012 mg/kg (LD50)
In vitro	Ceruletide is biologically and chemically identical to the human gastrointestinal hormones cholecystokinin-pancreatin (CCK) and gastrin II；Ceruletide stimulates gallbladder contraction while delaying gastric emptying and inhibiting motility of the proximal duodenum [1]. Ceruletide activates NF-κB/Rel in vitro at high doses (but not physiological doses), which may induce a self-defense gene program before cell damage occurs and may protect pancreatic acinar cells from further damage after secretagogue overstimulation [2].
In vivo	Ceruletide (5-15 ng/kg intravenously) has a significant spasmodic effect on the pylorus in rats[1]; Ceruletide (0.4-0.5 mcg/kg intravenously; 3-4 mcg/kg subcutaneously) causes vomiting and defecation in conscious dogs [3].
Disease Modeling Protocol	Establishment of chronic pancreatitis model Modeling Mechanism： Ceruletide acts on CCK receptors on pancreatic acinar cells, inducing dysregulation of digestive enzyme secretion, leading to cytoplasmic vacuolization, acinar cell death, edema, and inflammatory cell infiltration. Modeling Method： Experimental Subject：Mouse • C57BL/6J • 20-25 g • 6-7 weeks old Dosage and Administration Route：50 μg/kg • intraperitoneal injection (i.p.) Dosing Frequency and Duration Model：Three times per week for 4 consecutive weeks Validation： Pancreatic tissues stained with H&E, Masson's Trichrome, and Sirius Red exhibit typical pathological features of chronic pancreatitis, including glandular atrophy, stromal fibrosis, and inflammatory cell infiltration. Related Products： Taurocholic acid (TN2259).L-Arginine hydrochloride(T0670).Taurocholic acid sodium salt hydrate (T1138).L-Arginine(T3S0364).Acifluorfen (T40588).Sodium taurocholate (TWA2417) Precautions： Three days after the last cerulein injection, mice were sacrificed and pancreatic tissue samples were collected for observation. References：Li M,et.al. Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects. J Inflamm Res. 2022 Aug 3;15:4409-4420.
Synonyms	FI-6934, Cerulein, Caerulein

Chemical Properties

Molecular Weight	1352.4
Formula	C₅₈H₇₃N₁₃O₂₁S₂
Cas No.	17650-98-5
Smiles	CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Relative Density.	1.406g/cm3
Sequence	{pGlu}-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2
Sequence Short	{pGlu}-QD-Y(SO3H)-TGWMDF-NH2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (188.55 mM), Sonication is recommended.

H2O: 5 mg/mL (3.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (3.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7394 mL	3.6971 mL	7.3943 mL	36.9713 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.1479 mL	0.7394 mL	1.4789 mL	7.3943 mL
10 mM	0.0739 mL	0.3697 mL	0.7394 mL	3.6971 mL
20 mM	0.0370 mL	0.1849 mL	0.3697 mL	1.8486 mL
50 mM	0.0148 mL	0.0739 mL	0.1479 mL	0.7394 mL
100 mM	0.0074 mL	0.0370 mL	0.0739 mL	0.3697 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc