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Ceruletide

Catalog No. T14932 CAS 17650-98-5

Synonyms: Cerulein, Caerulein, FI-6934

Ceruletide (Caerulein) is a potent agonist of cholecystokinin receptor and it also is a safe and effective cholecystokinetic agent. It has a direct spasmogenic effect on the gallbladder muscle and bile ducts.

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Ceruletide, CAS 17650-98-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 162.00
5 mg	In stock	$ 457.00
10 mg	In stock	$ 636.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,360.00
100 mg	In stock	$ 1,830.00

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Purity: 97.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ceruletide (Caerulein) is a potent agonist of cholecystokinin receptor and it also is a safe and effective cholecystokinetic agent. It has a direct spasmogenic effect on the gallbladder muscle and bile ducts.
In vitro	Ceruletide is the same as biologically and chemically to the human gastrointestinal hormones cholecystokinin-pancreozymin (CCK) and gastrin II. Ceruletide stimulates gallbladder contraction while delaying gastric emptying and inhibiting motility in the proximal duodenum [1]. Ceruletide in supramaximal but not in physiological doses activate NF-kappaB/Rel in vitro. This activation may induce a self-defending genetic program before the onset of cellular injury and may prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation [2].
In vivo	Ceruletide (5-15 ng/kg, i.v.) shows a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduces blood pressure in anesthetized dogs [1]. Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) results in emesis and evacuation of the bowel in the intact conscious dog, and recovery is complete 15-30 min after i. v. administration and 2-4 hr after s.c. administration. Ceruletide SBA stimulation may perform as well as PP SBA stimulation in dogs with the portosystemic shunt and be more sensitive for the detection of hepatic dysfunction in dogs with the upper respiratory disease [3].

Synonyms	Cerulein, Caerulein, FI-6934
Molecular Weight	1352.4
Formula	C58H73N13O21S2
CAS No.	17650-98-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 96 mg/mL (70.98 mM)

H2O: 100 mg/mL (73.94 mM)

References and Literature

1. Vincent ME, et al. Pharmacology, clinical uses, and adverse effects of ceruletide, a cholecystokinetic agent. Pharmacotherapy. 1982 Jul-Aug;2(4):223-34. 2. Bridger N, et al. Comparison of postprandial and ceruletide serum bile acid stimulation in dogs. J Vet Intern Med. 2008 Jul-Aug;22(4):873-8. 3. Steinle AU, et al. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology. 1999 Feb;116(2):420-30. 4. Zarrindast MR, et al. Effects of cholecystokinin receptor agonist and antagonists on morphin dependence in mice. Pharmacol Toxicol. 1995 Dec;77(6):360-4.

Citations

1. Li M, Yuan Y, Han X, et al. Antioxidant Mitoquinone Alleviates Chronic Pancreatitis via Anti-Fibrotic and Antioxidant Effects. Journal of Inflammation Research. 2022, 15: 4409

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Peptide Compound Library Anti-Cancer Drug Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library NO PAINS Compound Library Natural Product Library Natural Product Library for HTS

Related Products

Related compounds with same targets

CCK Octapeptide, non-sulfated acetate Cholecystokinin (26-33) free acid Loxiglumide [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P acetate Spiroglumide N-Cbz-DL-tryptophan GV-150013X Lorglumide sodium salt

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Keywords

Ceruletide 17650-98-5 GPCR/G Protein cholecystokinin Cerulein Caerulein inhibit Cholecystokinin Receptor Inhibitor FI 6934 CCK Receptor FI-6934 FI6934 inhibitor

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