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Calhex 231 hydrochloride
🥰Excellent
Catalog No. T10666Cas No. 2387505-78-2
Alias Calhex231 hydrochloride
Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock.
Calhex 231 hydrochloride
🥰Excellent
Catalog No. T10666Alias Calhex231 hydrochlorideCas No. 2387505-78-2
Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $44 | In Stock | |
| 5 mg | $103 | In Stock | |
| 10 mg | $172 | In Stock | |
| 25 mg | $347 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $113 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Calhex 231 hydrochloride is the salt form of Calhex 231, a potent calcium-sensing receptor (CaSR) negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits oxidative stress and mir-208a-mediated mitochondrial fission for vasculoprotection and treatment of traumatic hemorrhagic shock. |
| Targets&IC50 | CaSR:0.39 μM |
| In vitro | Methods: LX-2 cells were treated with Calhex 231 hydrochloride (2.5, 5, 7.5, 10 μM, 48 hours), and cell viability was detected by MTT assay. Results: Calhex 231 hydrochloride could inhibit the growth of LX-2 cells, with an IC50 value of 9.5 μM. [4] |
| In vivo | Methods: Transverse aortic constriction (TAC) induced pressure overload and cardiac hypertrophy in male Wistar rats. Four weeks after TAC, rats were treated with Calhex 231 hydrochloride (10 μmol/kg, 4 weeks) for 4 weeks and analyzed 12 weeks after surgery. Rats were sacrificed and hearts were rapidly excised and weighed in cold (4 °C) buffer. The left and right ventricles were then isolated and weighed, and the left ventricular tissue was snap-frozen in liquid nitrogen and stored at -80 °C for subsequent western blot analysis. Results: Animals were observed to exhibit increases in interventricular septum (IVS) thickness, left ventricular posterior wall (LVPW) thickness, left ventricular internal dimension (LVID), left ventricular diastolic volume (LVDV), and left ventricular systolic volume (LVSV), as well as decreases in left ventricular fractional shortening (LVFS) and left ventricular ejection fraction (LVEF). [5] |
| Alias | Calhex231 hydrochloride |
| Molecular Weight | 443.41 |
| Formula | C25H28Cl2N2O |
| Cas No. | 2387505-78-2 |
| Smiles | [C@@H](N[C@@H]1[C@@H](NC(=O)C2=CC=C(Cl)C=C2)CCCC1)(C)C=3C4=C(C=CC3)C=CC=C4.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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