CGP 36216 hydrochloride

Name: CGP 36216 hydrochloride
Brand: TargetMol
SKU: T22647
Rating: 4.5 (1 reviews)

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Catalog No. T22647Cas No. 123691-29-2

CGP 36216 hydrochloride is a potent and selective antagonist of GABAB receptors (IC50: 43 μM).

CGP 36216 hydrochloride

😃Good

Catalog No. T22647Cas No. 123691-29-2

CGP 36216 hydrochloride is a potent and selective antagonist of GABAB receptors (IC50: 43 μM).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

CGP 36216 hydrochloride is a potent and selective antagonist of GABAB receptors (IC50: 43 μM).

In vitro

In rat neocortical preparations maintained in Mg2+-free Krebs medium, CGP 36216 acts as antagonism of baclofen-induced suppression of spontaneous discharges in a concentration-dependent manner. However, CGP 36216, up to 1 mM, was ineffective in antagonizing baclofen-induced hyperpolarisations, mediated through gamma-aminobutyric acid (B) GABAB postsynaptic receptors 1. In electrically stimulated brain slices preloaded with [3H] GABA, CGP 36216 increased the release of [3H] GABA, which was reversed by baclofen. While CGP 36216 is ineffective at GABAB postsynaptic receptors, it is appreciably more active at presynaptic receptors1.

Chemical Properties

Molecular Weight	151.14
Formula	C₅H₁₄NO₂P
Cas No.	123691-29-2
Relative Density.	1.108 g/cm3 (Predicted)

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: <18.76 mg/mL, Sonication is recommended. DMSO: <18.76 mg/mL, Sonication is recommended.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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