Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 μM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 3,470.00 | |
50 mg | 10-14 weeks | $ 4,580.00 | |
100 mg | 10-14 weeks | $ 6,400.00 |
Description | BRD-K98645985 is a BAF transcriptional repression inhibitor (EC50: ~2.37 μM). It binds ARID1A-specific BAF complexes, potently reverses HIV-1 latency and prevents nucleosomal positioning. |
Targets&IC50 | BAF transcriptional repression:2.37 μM (EC50) |
In vitro | In J-Lat T-cell line models, BRD-K98645985 treatment shows a concentration-dependent latency reversal. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting. BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in Bmi1, a 2.6-fold increase in Ring1, and a 3.3-fold decrease in Fgf4. |
Molecular Weight | 573.73 |
Formula | C33H43N5O4 |
CAS No. | 1357647-78-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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