Home Tools
Log in
Cart

BAY 73-6691

Catalog No. T10481L   CAS 794568-92-6
Synonyms: (R)-BAY 73-6691

BAY 73-6691 is an inhibitor of brain penetrant PDE9A.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BAY 73-6691 Chemical Structure
BAY 73-6691, CAS 794568-92-6
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 690.00
50 mg 6-8 weeks $ 897.00
100 mg 6-8 weeks $ 1,490.00
1 mL * 10 mM (in DMSO) 6-8 weeks $ 196.00
Bulk Inquiry
Get quote
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
In vitro BAY 73-6691 dose-dependently attenuates oxidative stress induced by Aβ25-35. The BAY 73-6691 dose-dependently alleviates cell viability loss due to Aβ25-35 treatment. The BAY 73-6691 attenuates Aβ25-35-induced increase of apoptosis cells[1]. It is found that when SH-SY5Y cells are cultured by Aβ25-35, a high degree of cell apoptosis is observed, while additional stimulation with BAY 73-6691 causes attenuation of cell apoptosis. BAY 73-6691 at 200 μg/mL almost neutralizes Aβ25-35-induced oxidative damage.
In vivo BAY 73-6691 dose-dependently improves the acquisition performance in the Aβ25-35-injected mice on days 7 to 10 (day 7, F(5,54)=65.153; day 8, F(5,54)=62.340; day 9, F(5,54)=37.529; day 10, F(5,54)=38.624; P<0.001) and it also dose-dependently elevates the Aβ25-35-induced decrease of the dwell time on the 10th day post Aβ25-35 injection (day 10, F(5,54)=27.360, P<0.001). BAY 73-6691 at 3 mg/kg can almost completely abolish the prolongation of escape-latency on days 9 to 10. Results reveal that the Aβ25-35 injection. BAY 73-6691 alleviates Aβ25-35-induced abnormalities of the above indices. BAY 73-6691 treatment cause no influence on the swimming speed. Treatment with BAY 73-6691 does not cause detectable alteration of spatial memory in sham mice. The BAY 73-6691 causes no influence on the four indices mentioned above in sham mice and it has no significant effect on the apoptosis of hippocampal neurons in sham mice[1].
Synonyms (R)-BAY 73-6691
Molecular Weight 356.73
Formula C15H12ClF3N4O
CAS No. 794568-92-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 160 mg/mL (448.52 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Li J, et al. Protective effects of BAY 73-6691, a selective inhibitor of phosphodiesterase 9, on amyloid-β peptides-induced oxidative stress in in-vivo and in-vitro models of Alzheimer's disease. Brain Res. 2016 Jul 1;1642:327-335.

Related Products

Related compounds with same targets
Torbafylline Doxofylline BIO-32546 K134 Choline theophyllinate Olprinone Mirodenafil dihydrochloride Milrinone

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BAY 73-6691 794568-92-6 Metabolism PDE BAY 736691 (R)-BAY 73-6691 BAY 73 6691 inhibitor inhibit

 

TargetMol