Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 62.00 | |
5 mg | In stock | $ 133.00 | |
10 mg | In stock | $ 226.00 | |
25 mg | In stock | $ 397.00 | |
50 mg | In stock | $ 597.00 | |
100 mg | In stock | $ 848.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 147.00 |
Description | Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively). |
Targets&IC50 | MMP13:0.27 μM, MMP9:17.52 μM, MMP8:22.39 μM, MMP3:12.87 μM |
In vivo | Apigenin-7-O-β-D-glucuronide (AG) suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation [2]. |
Source |
Synonyms | Apigenin 7-O-glucuronide |
Molecular Weight | 446.36 |
Formula | C21H18O11 |
CAS No. | 29741-09-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (112.02 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Apigenin-7-glucuronide 29741-09-1 Proteases/Proteasome MMP inhibit Apigenin 7-O-glucuronide Matrix metalloproteinases Inhibitor Apigenin7glucuronide Apigenin 7 glucuronide inhibitor