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Amino-bis-PEG3-TCO

Catalog No. T17401 CAS T17401

Amino-bis-PEG3-TCO is a three-unit cleavable polyethylene glycol (PEG) linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

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Amino-bis-PEG3-TCO, CAS T17401

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amino-bis-PEG3-TCO is a three-unit cleavable polyethylene glycol (PEG) linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
In vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Molecular Weight	888.1
Formula	C43H77N5O14
CAS No.	T17401

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Dose Conversion

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Amino-bis-PEG3-TCO T17401 Others AminobisPEG3TCO Amino-bis-PEG-3-TCO Amino bis PEG3 TCO inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.