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Alisporivir

Catalog No. T14180 CAS 254435-95-5

Synonyms: DEB-025, Debio-025

Alisporivir (Debio-025) is a cyclophilin inhibitor molecule.It has potent anti-hepatitis C virus (HCV) activity.

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Alisporivir, CAS 254435-95-5

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 1,160.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Alisporivir (Debio-025) is a cyclophilin inhibitor molecule.It has potent anti-hepatitis C virus (HCV) activity.
In vitro	Alisporivir (Debio-025) is a cyclosporine A analog and introduces a novel category of cyclophilin inhibitors without immunosuppressive effects. It targets CypA, vital for HCV replication, by inhibiting its action which is necessary for the virus's survival[1]. Additionally, Alisporivir disrupts the HCV protein's harmful impact on mitochondrial membrane potential, safeguarding mitochondrial function from virus-induced collapse without causing apoptosis, calcium overload, or reactive oxygen species (ROS) production[2]. It also promotes antigen presentation in hepatoma cells, thereby boosting the activation of antigen-specific CD8+ T cells by 40% and increasing MHC-I and beta-2 microglobulin expression across various cell lines, indicating an enhanced immune response[4]. In studies, low doses effectively halted SARS-CoV and MERS-CoV replication within cellular models. Notably, pairing alisporivir with ribavirin further amplified its efficacy against MERS-CoV in these contexts[3].
In vivo	Combination treatment with alisporivir and ribavirin does not protect against SARS-CoV infection in a mouse model[3].

Synonyms	DEB-025, Debio-025
Molecular Weight	1216.64
Formula	C63H113N11O12
CAS No.	254435-95-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (82.19 mM)

References and Literature

1. Coelmont L, et al. DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. PLoS One. 2010 Oct 27;5(10):e13687. 2. Quarato G, et al. The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction. Hepatology. 2012 May;55(5):1333-43. 3. de Wilde AH, et al. Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model. Virus Res. 2017 Jan 15;228:7-13. 4. Esser-Nobis K, et al. The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation. J Hepatol. 2016 Jun;64(6):1305-14.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alisporivir 254435-95-5 Others DEB025 DEB-025 Debio-025 DEB 025 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.