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GPCR/G Protein Adiponectin receptor AdipoRon

AdipoRon

Catalog No. T2257   CAS 924416-43-3
Synonyms: SC-396658

AdipoRon is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).

AdipoRon, CAS 924416-43-3
Pack Size Availability Price/USD Quantity
5 mg In stock 45.00
10 mg In stock 54.00
25 mg In stock 122.00
50 mg In stock 194.00
100 mg In stock 252.00
200 mg In stock 327.00
1 mL * 10 mM (in DMSO) In stock 59.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AdipoRon is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).
Targets&IC50 AdipoR1 : 1.8μM(Kd),   AdipoR2 : 3.1μM(Kd),  
Cell Research
The effects of AdipoRon on the proliferation of parenchymal and non-parenchymal hepatocytes are evaluated in vitro via L02 and RAW264.7, by MTT assay as described with slight modification: 100 μL cells suspension (6×104/mL) are seeded in a 96-well plate and incubated for 18 h. Fresh media with AdipoRon are added at specified concentrations, and the incubations continue for a further 24 h. Then cells are incubated for 4 h with 0.5 mg/mL of MTT, and analyzed in a microplate reader at 490 nm. Each group is performed in six replications. The mean absorbance values corrected for a blank (medium only) are calculated as percentages of survival.
Animal Research
Animal Model: Mice
Synonyms SC-396658
Purity 99.63%
Molecular Weight 428.52
Formula C27H28N2O3
CAS No. 924416-43-3

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 80 mg/mL (186.7 mM)

Ethanol: 47 mg/mL (109.7 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Okada-Iwabu M, et al. Nature. 2013, 503(7477), 493-499. 2. Zhang Y, et al. AdipoRon, the first orally active adiponectin receptor activator, attenuates postischemic myocardial apoptosis through both AMPK-mediated and AMPK-independent signalings. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E275-82. 3. Wang Y, et al. Hepatoprotective effects of AdipoRon against d-galactosamine-induced liver injury in mice. Eur J Pharm Sci. 2016 Aug 9;93:123-131. 4. Hong K, et al. Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action. Microcirculation. 2016 Apr;23(3):207-20.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library GPCR Compound Library

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AdipoRon Ticlopidine Gramine

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