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AdipoRon

Catalog No. T2257 CAS 924416-43-3

Synonyms: SC-396658

AdipoRon (SC-396658) is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AdipoRon, CAS 924416-43-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 109.00
50 mg	In stock	$ 173.00
100 mg	In stock	$ 226.00
200 mg	In stock	$ 293.00
500 mg	In stock	$ 495.00
1 g	In stock	$ 719.00
1 mL * 10 mM (in DMSO)	In stock	$ 53.00

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Purity: 99.86%

Purity: 99.63%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AdipoRon (SC-396658) is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).
Targets&IC50	AdipoR2:3.1 μM(Kd), AdipoR1:1.8 μM(Kd)
In vitro	In wild-type mice, AdipoRon administered orally (50 mg/kg) activates the AdipoR2–PPAR-α pathway in the liver or the AdipoR1–AMPK–PGC-1α pathway in skeletal muscle, thereby improving insulin resistance, lipid abnormalities, and glucose tolerance. In the skeletal muscle and liver of WT mice, AdipoRon (50 mg/kg, intravenously) significantly induces phosphorylation of AMPK via AdipoR1/2. Furthermore, AdipoRon ameliorates diabetic symptoms in the genetic obesity murine model db/db mice and extends the shortened lifespan of db/db mice on a high-fat diet.
In vivo	AdipoRon, through its interaction with AdipoR1/2 in C2C12 myotubes, enhances the activation of AMPK and promotes the expression of PGC-1α as well as mitochondrial biogenesis.
Cell Research	The effects of AdipoRon on the proliferation of parenchymal and non-parenchymal hepatocytes are evaluated in vitro via L02 and RAW264.7, by MTT assay as described with slight modification: 100 μL cells suspension (6×104/mL) are seeded in a 96-well plate and incubated for 18 h. Fresh media with AdipoRon are added at specified concentrations, and the incubations continue for a further 24 h. Then cells are incubated for 4 h with 0.5 mg/mL of MTT, and analyzed in a microplate reader at 490 nm. Each group is performed in six replications. The mean absorbance values corrected for a blank (medium only) are calculated as percentages of survival.

Synonyms	SC-396658
Molecular Weight	428.52
Formula	C27H28N2O3
CAS No.	924416-43-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 47 mg/mL (109.7 mM)

DMSO: 80 mg/mL (186.7 mM)

References and Literature

1. Okada-Iwabu M, et al. Nature. 2013, 503(7477), 493-499.

Citations

1. He Z, Liu S, Li Z, et al. Coaxial TP/APR electrospun nanofibers for programmed controlling inflammation and promoting bone regeneration in periodontitis-related alveolar bone defect models. Materials Today Bio. 2022: 100438. 2. Yang J, Wang Z X, Fang L, et al. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221. Journal of Ethnopharmacology. 2023, 300: 115688.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Orally Active Compound Library Anti-Obesity Compound Library Anti-Metabolism Disease Compound Library Bioactive Compound Library NO PAINS Compound Library Human Metabolite Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AdipoRon 924416-43-3 GPCR/G Protein Adiponectin receptor Adiponectin Receptor AdipoRs SC 396658 SC-396658 Inhibitor SC396658 inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.