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AdipoRon

Catalog No. T2257 CAS 924416-43-3

Synonyms: SC-396658

AdipoRon is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AdipoRon, CAS 924416-43-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AdipoRon is an orally bioavailable adiponectin receptor agonist. It can combine with AdipoR1/2 (KD: 1.8/3.1 μM).
Targets&IC50	AdipoR2:3.1 μM(Kd), AdipoR1:1.8 μM(Kd)
Cell Research	The effects of AdipoRon on the proliferation of parenchymal and non-parenchymal hepatocytes are evaluated in vitro via L02 and RAW264.7, by MTT assay as described with slight modification: 100 μL cells suspension (6×104/mL) are seeded in a 96-well plate and incubated for 18 h. Fresh media with AdipoRon are added at specified concentrations, and the incubations continue for a further 24 h. Then cells are incubated for 4 h with 0.5 mg/mL of MTT, and analyzed in a microplate reader at 490 nm. Each group is performed in six replications. The mean absorbance values corrected for a blank (medium only) are calculated as percentages of survival.

Synonyms	SC-396658
Molecular Weight	428.52
Formula	C27H28N2O3
CAS No.	924416-43-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 47 mg/mL (109.7 mM)

DMSO: 80 mg/mL (186.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Okada-Iwabu M, et al. Nature. 2013, 503(7477), 493-499.

Citations

1. He Z, Liu S, Li Z, et al. Coaxial TP/APR electrospun nanofibers for programmed controlling inflammation and promoting bone regeneration in periodontitis-related alveolar bone defect models. Materials Today Bio. 2022: 100438. 2. Yang J, Wang Z X, Fang L, et al. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221. Journal of Ethnopharmacology. 2023, 300: 115688.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AdipoRon 924416-43-3 GPCR/G Protein Adiponectin receptor Adiponectin Receptor AdipoRs Inhibitor inhibit SC-396658 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.