Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in studies to reverse arrhythmias.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 210.00 | |
5 mg | In stock | $ 530.00 | |
10 mg | In stock | $ 766.00 | |
25 mg | In stock | $ 1,180.00 | |
50 mg | In stock | $ 1,590.00 | |
100 mg | In stock | $ 2,150.00 | |
500 mg | In stock | $ 4,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 597.00 |
Description | AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in studies to reverse arrhythmias. |
Targets&IC50 | Inalate:4.3 microM, Inapeak:66 microM |
In vitro | AZD1305 (0.1–30 µM, n = 6, each concentration applied for 3 min ; dog cardiomyocytes) concentration-dependently blocked INalate (IC50=4.3 microM) and INapeak (IC50=66 microM). In PFs, E-4031, but not AZD1305, markedly prolonged APD90 (from 380+/-15 to 597+/-86 ms, P<0.05) after the long CL and augmented APD90 instability (2+/-0.4 to 24+/-6.1 ms, P<0.05), increases significantly attenuated by AZD1305 and lidocaine.[3] |
In vivo | AZD1305 ((36g/kg/min intravenously for 30 minutes ; anesthetized mongrel dogs) respectively increased QT and RR intervals from 290±7 to 397±15 ms (+37%, P<0.0001) and from 603±22 to 778±32 ms (+29%, P=0.002) at normal sinus rhythm. AZD1305 increased the QT interval from 535±28 to 747±36 ms (+40%, P<0.0001). AZD1305 slightly slowed the idioventricular rhythm.[2] |
Synonyms | UNII-CZO834LXQM, AZD 1305 |
Molecular Weight | 434.5 |
Formula | C22H31FN4O4 |
CAS No. | 872045-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (57.54 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZD-1305 872045-91-5 Others AZD1305 UNII-CZO834LXQM AZD 1305 inhibitor inhibit