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AN3199

Catalog No. T10316 CAS 1187187-10-5

AN3199 is a selective inhibitor of <a href="/target/PDE" style="display: inline; color: #c13a36">PDE</a>4 with an IC50 of 94.5 nM.

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AN3199, CAS 1187187-10-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 86.00
10 mg	In stock	$ 138.00
25 mg	In stock	$ 275.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 677.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.
Targets&IC50	PDE4:94.5 nM (IC50)

Molecular Weight	327.14
Formula	C17H18BNO5
CAS No.	1187187-10-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90.0 mg/mL (275.1 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhang YK, et al. Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2270-4. 2. Akama Tsutomu, et al. Preparation of boron-containing small molecules as anti-inflammatory agents. From PCT Int. Appl. (2009), WO 2009111676 A2 20090911.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Pterine-6-carboxylic acid Norbraylin Vardenafil dihydrochloride PF-05180999 PAT-048 K134 PAT-505 OR-1896

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AN3199 1187187-10-5 Metabolism Others PDE AN-3199 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.