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6H05

Catalog No. T1931   CAS 1469338-01-9
Synonyms: K-Ras inhibitor

6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).

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6H05 Chemical Structure
6H05, CAS 1469338-01-9
Pack Size Availability Price/USD Quantity
5 mg 4-6 weeks $ 129.00
10 mg 4-6 weeks $ 226.00
25 mg 4-6 weeks $ 374.00
50 mg 4-6 weeks $ 555.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
Kinase Assay Measurement of NF-κB transcriptional activity: Macrophages RAW 264.7 transfected stably with reporter plasmid of pNF-κB-SEAP-NPT are treated with 1 μg/ml LPS and/or sample for 16 hours. As the reporter, SEAP activity in the cell-free culture media is measured as followed. Single cell-derived stable transfectants are plated in 5 ml of T-25 flask, and the media is decanted 24 h later. At this time, cells are washed twice with phosphate-buffered saline, and incubations are initiated by addition of new media. Chemicals are added to the culture medium after 24 h of incubations. Aliquots (25 ml) of medium from a control or chemical-treated cultures are taken at 0, 3, 20, 24, 48, and 72 h, heated at 65°C for 5 min to eliminate the alkaline phosphatase activity, and used immediately or stored at -20°C. Mixtures consisting of dilution buffer (25 ml), assay buffer (97 ml), culture media (25 ml), and 4-methylumbelliferyl phosphate (MUP, 1 mM, 3 ml) in each well of the 96-well plates are incubated for 60 min in the dark at room temperature. Fluorescence emits the product of the SEAP/MUP is measured at 449 nm using a 96-well plate fluorometer after excitation at 360 nm.
Synonyms K-Ras inhibitor
Molecular Weight 476.12
Formula C20H30ClN3O2S3
CAS No. 1469338-01-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

TargetMolReferences and Literature

1. Ostrem JM, et al. Nature. 2013, 503(7477), 548-551.

Related compound libraries

This product is contained In the following compound libraries:
Fluorochemical Library

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K-Ras(G12C) inhibitor 9 AZ304 GW 5074 Agerafenib Rineterkib AD80 K-Ras-IN-1 Griffipavixanthone

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Keywords

6H05 1469338-01-9 GPCR/G Protein MAPK Ras Raf Inhibitor K-Ras inhibitor 6H-05 inhibit inhibitor

 

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