Powder: -20°C for 3 years | In solvent: -80°C for 1 year
5-Ethynyluridine can be used to label newly synthesized RNA. This approach, named capture of the newly transcribed RNA interactome using click chemistry (RICK), systematically captures proteins bound to a wide range of RNAs, including nascent RNAs and traditionally neglected nonpolyadenylated RNAs.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 148.00 | |
50 mg | In stock | $ 263.00 | |
100 mg | In stock | $ 382.00 | |
200 mg | In stock | $ 573.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | 5-Ethynyluridine can be used to label newly synthesized RNA. This approach, named capture of the newly transcribed RNA interactome using click chemistry (RICK), systematically captures proteins bound to a wide range of RNAs, including nascent RNAs and traditionally neglected nonpolyadenylated RNAs. |
In vivo | EU labelling can be used to examine transcription in vivo in mouse models of nervous system disorders. Injection of EU directly into the cerebellum results in reproducible labelling of newly transcribed RNA in cerebellar neurons and glia, with cell type-specific differences in relative labelling intensities, such as Purkinje cells exhibiting the highest levels. EU-labelling accumulating into cytoplasmic inclusions, indicating that EU, like other modified uridines, may introduce non-physiological properties in labelled RNAs[1]. |
Molecular Weight | 268.22 |
Formula | C11H12N2O6 |
CAS No. | 69075-42-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 10 mg/mL
PBS (pH 7.2): 5 mg/mL
DMSO: 10 mg/mL
You can also refer to dose conversion for different animals. More
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5-Ethynyluridine 69075-42-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog 5-EU neurons purkinje cells Inhibitor nascent RNA 5 Ethynyluridine RNA transcripts 5Ethynyluridine inhibit inhibitor