Shopping Cart

Remove All
Your shopping cart is currently empty

Proceed to checkout Continue shopping

25,26-Dihydroxyvitamin D3

Name: 25,26-Dihydroxyvitamin D3
Brand: TargetMol
SKU: T13490
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T13490Cas No. 29261-12-9

Alias 25,26-Dihydroxycholecalciferol

25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a vitamin D3 metabolite and a precursor compound for the synthesis of 25-hydroxyvitamin D.

25,26-Dihydroxyvitamin D3

😃Good

Purity: 95.47%

Catalog No. T13490Alias 25,26-DihydroxycholecalciferolCas No. 29261-12-9

25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a vitamin D3 metabolite and a precursor compound for the synthesis of 25-hydroxyvitamin D.

Pack Size	Price	Availability	Quantity
1 mg	$2,318	Backorder

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:95.47%

Resource Download

COA

Product Introduction

Bioactivity

Description	25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a vitamin D3 metabolite and a precursor compound for the synthesis of 25-hydroxyvitamin D.
In vitro	24,25 and 25,26 diOHD3 (0.125-0.250 mug) were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The 'bone calcium mobilization' of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3 [2].
In vivo	24,25 and 25,26-Dihydroxyvitamin D3 (0.125-0.250 mug) were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26-Dihydroxyvitamin D3 increased serum calcium moderately, but the increment was only significant with 24,25-Dihydroxyvitamin D3 [2].
Synonyms	25,26-Dihydroxycholecalciferol

Chemical Properties

Molecular Weight	416.64
Formula	C₂₇H₄₄O₃
Cas No.	29261-12-9
Smiles	C[C@@]12[C@](\C(=C\C=C\3/C(=C)CC[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCC(CO)(C)O)C)[H])[H]
Relative Density.	1.06g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (192.01 mM.), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4002 mL	12.0008 mL	24.0015 mL	120.0077 mL
5 mM	0.4800 mL	2.4002 mL	4.8003 mL	24.0015 mL
10 mM	0.2400 mL	1.2001 mL	2.4002 mL	12.0008 mL
20 mM	0.1200 mL	0.6000 mL	1.2001 mL	6.0004 mL
50 mM	0.0480 mL	0.2400 mL	0.4800 mL	2.4002 mL
100 mM	0.0240 mL	0.1200 mL	0.2400 mL	1.2001 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc