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1-Naphthaleneacetic acid

Name: 1-Naphthaleneacetic acid
Brand: TargetMol
SKU: TMO2790
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMO2790Cas No. 86-87-3

Alias α-Naphthaleneacetic acid, Transplantone, Phyomone, 1-Naphthylacetic acid

1-Naphthaleneacetic acid (Transplantone) , is widely used in agriculture for various purposes. It is a synthetic plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.

1-Naphthaleneacetic acid

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Purity: 98.67%

Catalog No. TMO2790Alias α-Naphthaleneacetic acid, Transplantone, Phyomone, 1-Naphthylacetic acidCas No. 86-87-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.67%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

1-Naphthaleneacetic acid AI Summary

1-Naphthaleneacetic acid exhibits a diverse array of bioactivities. Notably, it acts as an inhibitor against rat lens aldose reductase with a noncompetitive inhibition type and an IC50 of 32000.0 nM. Further, it inhibits the human T1R2/T1R3 receptor in HEK293E cells with an IC50 of 233,000.0 nM by blocking sucralose-induced intracellular calcium mobilization. Additionally, it demonstrates inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), modulation of lipid storage in Drosophila cells, and inhibition of ELG1-dependent DNA repair. 1-Naphthaleneacetic acid also acts as a delayed death inhibitor of the malarial parasite plastid, an inhibitor of Polymerase Iota, and an agonist for thyroid hormone receptor beta and peroxisome proliferator-activated receptor gamma signaling. Moreover, it induces DNA re-replication in colon adenocarcinoma cells, causes synthetic lethality in tumor cells producing 2HG, and blocks Ebola Virus entry in various assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1-Naphthaleneacetic acid (Transplantone) , is widely used in agriculture for various purposes. It is a synthetic plant hormone in the auxin family and is an ingredient in many commercial plant rooting horticultural products.
Targets&IC50	PLA2:13.16 μM (IC50)
Synonyms	α-Naphthaleneacetic acid, Transplantone, Phyomone, 1-Naphthylacetic acid

Chemical Properties

Molecular Weight	186.21
Formula	C₁₂H₁₀O₂
Cas No.	86-87-3
Smiles	OC(=O)CC1=CC=CC2=CC=CC=C12
Relative Density.	1.263 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (349.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3703 mL	26.8514 mL	53.7028 mL	268.5140 mL
5 mM	1.0741 mL	5.3703 mL	10.7406 mL	53.7028 mL
10 mM	0.5370 mL	2.6851 mL	5.3703 mL	26.8514 mL
20 mM	0.2685 mL	1.3426 mL	2.6851 mL	13.4257 mL
50 mM	0.1074 mL	0.5370 mL	1.0741 mL	5.3703 mL
100 mM	0.0537 mL	0.2685 mL	0.5370 mL	2.6851 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc