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(S,R,S)-AHPC-PEG3-N3

Catalog No. T17909 CAS 1797406-80-4

Synonyms: VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12

(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

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(S,R,S)-AHPC-PEG3-N3, CAS 1797406-80-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 37.00
5 mg	In stock	$ 57.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 153.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 289.00

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Purity: 98.83%

Purity: 98.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
In vitro	(S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed with an A-L-B structure that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compound via a suitable linker[1][2].

Synonyms	VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12
Molecular Weight	645.77
Formula	C30H43N7O7S
CAS No.	1797406-80-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (77.43 mM), Sonification is recommended.

References and Literature

1. CIULLI, Alessio, et al. DERIVATIVES OF 1-[(CYCLOPENTYL OR 2-PYRROLIDINYL)CARBONYLAMINOMETHYL]-4-(1,3-THIAZOL-5-YL) BENZENE WHICH ARE USEFUL FOR THE TREATMENT OF PROLIFERATIVE, AUTOIMMUNE OR INFLAMMATORY DISEASES. WO2016146985A1. 2. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

Related Products

Related compounds with same targets

(S,S,S)-AHPC hydrochloride Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Lenalidomide-Br CC-885 Pomalidomide-PEG4-Ph-NH2 Pomalidomide-C2-NH2 hydrochloride Thalidomide-O-COOH (S,R,S)-AHPC-PEG4-NH2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(S,R,S)-AHPC-PEG3-N3 1797406-80-4 Others PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase (S,R,S) AHPC PEG3 N3 (S,R,S)-AHPC-PEG-3-N3 Inhibitor inhibit E3 Ligase Ligand-Linker Conjugates VHL Ligand-Linker Conjugates 8 AHPC-PEG3-N3 VH032-PEG3-N3 (S,R,S)AHPCPEG3N3 E3 ligase Ligand-Linker Conjugates 12 inhibitor

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