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(±)-Taxifolin

Name: (±)-Taxifolin
Brand: TargetMol
SKU: T40080
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40080Cas No. 24198-97-8

Alias (±)-Dihydroquercetin

(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin, a flavonoid with anti-tyrosinase and anti-fibrotic activity, commonly found in onion, silymarin, French maritime pine bark, and Douglas fir bark. It inhibits collagenase with an IC50 value of 193.3 μM and acts as a free radical scavenger with antioxidant capacity.

(±)-Taxifolin

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Purity: 97.23%

Catalog No. T40080Alias (±)-DihydroquercetinCas No. 24198-97-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.23%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	(±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin, a flavonoid with anti-tyrosinase and anti-fibrotic activity, commonly found in onion, silymarin, French maritime pine bark, and Douglas fir bark. It inhibits collagenase with an IC50 value of 193.3 μM and acts as a free radical scavenger with antioxidant capacity.
Targets&IC50	Collagenase:193.3 μM
In vivo	Taxifolin (10 mg/kg; AD model mice) treatment also significantly prevented the decreased expression levels of PSD 95 induced by Aβ42. A live cell imaging study showed that a 2 h pre-treatment of taxifolin prevented the decrease in the number of filopodium and spine induced by Aβ42 oligomers.[3]
Synonyms	(±)-Dihydroquercetin

Chemical Properties

Molecular Weight	304.25
Formula	C₁₅H₁₂O₇
Cas No.	24198-97-8
Smiles	O=C1C=2C(O[C@@H]([C@H]1O)C3=CC(O)=C(O)C=C3)=CC(O)=CC2O

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 18 mg/mL (59.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.2868 mL	16.4339 mL	32.8677 mL	164.3385 mL
5 mM	0.6574 mL	3.2868 mL	6.5735 mL	32.8677 mL
10 mM	0.3287 mL	1.6434 mL	3.2868 mL	16.4339 mL
20 mM	0.1643 mL	0.8217 mL	1.6434 mL	8.2169 mL
50 mM	0.0657 mL	0.3287 mL	0.6574 mL	3.2868 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc