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β-Aminoarteether

Catalog No. T38723 CAS 133162-24-0

Synonyms: β-Aminoarteether, SM934 free base

β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.

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β-Aminoarteether, CAS 133162-24-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
5 mg	In stock	$ 448.00
10 mg	In stock	$ 658.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,380.00
100 mg	In stock	$ 1,890.00
500 mg	In stock	$ 3,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 443.00

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Purity: 97.02%

Purity: 96.09%

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Chemical Properties

Storage & Solubility Information

Description	β-Aminoarteether (SM934 free base), an orally active derivative of Artemisinin, serves a pivotal role in the research of inflammation and autoimmune disorders, including those related to lupus diseases.
In vitro	β-Aminoarteether (SM934; 10 μM; 24 hours) directly increases IL-10 production and reduces IL-12/23p40 production in primary peritoneal macrophages upon IFN-γ stimulation [1]. Additionally, in vitro, β-Aminoarteether (SM934) inhibits Th1 and Th17 polarization without affecting Treg differentiation [1].
In vivo	Treatment with β-Aminoarteether (SM934; orally administered at doses of 1-10 mg/kg daily for 3 months) substantially slowed the advancement of glomerulonephritis and enhanced survival rates in female NZB/W F1 mice aged six and a half months [1]. Additionally, β-Aminoarteether therapy bolstered the production of IL-10 by macrophages derived from these mice [1]. This indicates a promising therapeutic potential for managing glomerulonephritis in this mouse model.

Synonyms	β-Aminoarteether, SM934 free base
Molecular Weight	327.42
Formula	C17H29NO5
CAS No.	133162-24-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (183.25 mM)

References and Literature

1. Li-Fei Hou, et al. SM934 treated lupus-prone NZB × NZW F1 mice by enhancing macrophage interleukin-10 production and suppressing pathogenic T cell development. PLoS One. 2012;7(2):e32424.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Clinical Compound Library Bioactive Compounds Library Max

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Keywords

β-Aminoarteether 133162-24-0 Others SM934 free base SM-934 beta-Aminoarteether SM934 SM 934 b-Aminoarteether inhibitor inhibit

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