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(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
🥰Excellent
Catalog No. T9691L
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane.
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
🥰Excellent
Purity: 96.84%
Catalog No. T9691L
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $67 | In Stock | |
| 5 mg | $163 | In Stock | |
| 10 mg | $236 | In Stock | |
| 25 mg | $378 | In Stock | |
| 50 mg | $511 | In Stock | |
| 100 mg | $690 | In Stock | |
| 200 mg | $928 | In Stock |
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Purity:96.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane. |
| Targets&IC50 | PTH:69 nM(Ki) |
| In vitro | In opossum kidney (OK) cells, (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (0.05-10 μM) inhibits PTHrP or PTH-stimulated cAMP formation in causes a concentration-dependent manner. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (0.1-10 μM) attenuates the inhibition of NapiT promoted by 1 nM of either PTHrP or PTH[1]. |
| In vivo | In hypercalcemic athymic nude mice bearing a human squamous cell carcinoma of the lung, administration of (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate (1 mg/mL once, 0.1 mg/mL for 6 h; i.v.) has no significant effect on serum calcium levels[2]. |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 50 mg/mL, Sonication is recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Thyroidhormonereceptor(THR)ThyroidhormonereceptorThyroid hormone receptor(THR)Thyroid hormone receptorTHR(D-Trp-12,Tyr34)-pTH (7-34) amide (bovine) acetate(DTrp12,Tyr34)pTH (734) amide (bovine) acetate(D-Trp12,Tyr34)-pTH amide Acetate(D-Trp12,Tyr34)-pTH(D Trp12,Tyr34) pTH (7 34) amide (bovine) acetate
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