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β-catenin-IN-37

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Catalog No. T39200Cas No. 1783856-40-5

β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.

β-catenin-IN-37

β-catenin-IN-37

😃Good
Catalog No. T39200Cas No. 1783856-40-5
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
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Product Introduction

Bioactivity
Description
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
In vitro
'β-catenin-IN-37 exhibits affinity for the β-catenin/Tcf protein-protein interaction (PPI), demonstrating dissociation constants (K_i values) of 17 μM and 18 μM in fluorescence polarization (FP) assay and AlphaScreen assay, respectively[1].'
Chemical Properties
Molecular Weight307.277
FormulaC13H9N9O
Cas No.1783856-40-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

β-catenin-IN-37βcateninIN37β catenin IN 37beta-catenin-IN-37b-catenin-IN-37
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