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N,N-Dimethylacetamide

Name: N,N-Dimethylacetamide
Brand: TargetMol
SKU: T19439
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19439Cas No. 127-19-5

Alias DMAc

N,N-Dimethylacetamide (DMAc) is a drug excipient with blood-brain barrier permeability and anti-inflammatory activity, acting through inhibition of the NF-κB signaling pathway. N,N-Dimethylacetamide can reduce endotoxin-induced inflammatory responses in vivo.

N,N-Dimethylacetamide

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Purity: 99.13%

Catalog No. T19439Alias DMAcCas No. 127-19-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$34	-	In Stock
1 g	$48	-	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.13%

Appearance:Liquid

Color:Transparent

Resource Download

COA GC HNMR

Product Introduction

Bioactivity

Description	N,N-Dimethylacetamide (DMAc) is a drug excipient with blood-brain barrier permeability and anti-inflammatory activity, acting through inhibition of the NF-κB signaling pathway. N,N-Dimethylacetamide can reduce endotoxin-induced inflammatory responses in vivo.
In vitro	Methods: RAW 264.7 cells were treated with N,N-Dimethylacetamide (0-1000μM), and cell viability was determined by MTT assay. Results: N,N-Dimethylacetamide inhibited the bactericidal activity of macrophages in RAW 264.7 cells.[1]
In vivo	Methods: N,N-Dimethylacetamide (0.2, 0.39, 0.78, 1.56, 3.1 mg/kg, intraperitoneal injection) was used to treat LPS-induced C57BL/6 embryonic day (E) 15.5 mice. Results: N,N-Dimethylacetamide prevented LPS-triggered premature birth in C57BL/6 embryonic day (E) 15.5 mice in a concentration-dependent manner.[1]
Synonyms	DMAc

Chemical Properties

Molecular Weight	87.12
Formula	C₄H₉NO
Cas No.	127-19-5
Smiles	O=C(N(C)C)C
Relative Density.	0.94 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (918.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	11.4784 mL	57.3921 mL	114.7842 mL	573.9210 mL
5 mM	2.2957 mL	11.4784 mL	22.9568 mL	114.7842 mL
10 mM	1.1478 mL	5.7392 mL	11.4784 mL	57.3921 mL
20 mM	0.5739 mL	2.8696 mL	5.7392 mL	28.6961 mL
50 mM	0.2296 mL	1.1478 mL	2.2957 mL	11.4784 mL
100 mM	0.1148 mL	0.5739 mL	1.1478 mL	5.7392 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc