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Men 10376 TFA(135306-85-3,free)
🥰Excellent
Catalog No. TP1086
Alias Neurokinin-2 receptor antagonist TFA, Men 10376 TFA
Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
Men 10376 TFA(135306-85-3,free)
🥰Excellent
Purity: 99.22%
Catalog No. TP1086Alias Neurokinin-2 receptor antagonist TFA, Men 10376 TFA
Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $181 | In Stock | |
| 5 mg | $448 | In Stock | |
| 10 mg | $659 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,380 | In Stock | |
| 100 mg | $1,890 | In Stock |
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Purity:99.22%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Men 10376 TFA(135306-85-3,free) (Neurokinin-2 receptor antagonist TFA) is an effective and selective tachykinin nk-2 receptor antagonist with a K I value of 4.4 M for the nk-2 receptor in the small intestine of rats. |
| Targets&IC50 | NK2:Ki: 4.4 μM (rat small intestine) |
| In vitro | Men 10376 is a selective tachykinin NK-2 receptor, with a Ki of 4.4 μM, and shows low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). Men 10376 shows no effect on NK-3 receptor (Ki, >10 μM)[2]. |
| In vivo | Men 10376 (1 and 3 μmol/kg) antagonizes increase in bladder motility produced by the NK-2 receptor agonist in rats[2]. |
| Synonyms | Neurokinin-2 receptor antagonist TFA, Men 10376 TFA |
| Molecular Weight | 1195.25 |
| Formula | C59H69F3N12O12 |
| Smiles | CC([C@H](NC([C@H](NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC1=CC=C(O)C=C1)=O)CC2=CNC3=CC=CC=C32)=O)C(N[C@@H](C(N[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)CC4=CNC5=CC=CC=C54)=O)CC6=CNC7=CC=CC=C76)=O)C.OC(C(F)(F)F)=O |
| Relative Density. | no data available |
| Sequence | Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2 |
| Sequence Short | DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | H2O: 1.43 mg/mL (1.20 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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