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Casein kinase 1δ-IN-1
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Catalog No. T60295Cas No. 851871-94-8
Alias WAY-643895
Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ) and can be utilized in the study of neurodegenerative diseases, such as Alzheimer's disease.
Casein kinase 1δ-IN-1
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Purity: 99.89%
Catalog No. T60295Alias WAY-643895Cas No. 851871-94-8
Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ) and can be utilized in the study of neurodegenerative diseases, such as Alzheimer's disease.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $30 | In Stock | In Stock | |
| 25 mg | $53 | In Stock | In Stock | |
| 50 mg | $81 | In Stock | In Stock | |
| 100 mg | $123 | In Stock | In Stock | |
| 200 mg | $179 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
Casein kinase 1δ-IN-1 AI Summary
Casein kinase 1δ-IN-1 exhibits a broad spectrum of bioactivity as an inhibitor across various biological assays. It shows moderate potency in inhibiting Human Jumonji Domain Containing 2E (JMJD2E) and significant potency in inhibiting ROR gamma transcriptional activity. Additionally, it demonstrates moderate to high potency against enzymes and proteins such as Aldehyde Dehydrogenase 1 (ALDH1A1), Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), Influenza NS1 Protein Function, Fructose-1,6-bisphosphate Aldolase, and Histone Lysine Methyltransferase G9a. Casein kinase 1δ-IN-1 also targets proteins like BAZ2B and pathways like Chronic Active B-Cell Receptor Signaling and Nrf2 activation. Furthermore, it inhibits DNA repair processes, malarial parasite plastid function, firefly luciferase, GLP-1 Receptor, ARNT/TAC3 interactions, and TDP-43 function. Overall, Casein kinase 1δ-IN-1 is notable for its diverse inhibitory bioactivity across numerous targets..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ) and can be utilized in the study of neurodegenerative diseases, such as Alzheimer's disease. |
| Synonyms | WAY-643895 |
| Molecular Weight | 229.26 |
| Formula | C11H7N3OS |
| Cas No. | 851871-94-8 |
| Smiles | O=C(Nc1sccc1C#N)c1ccccn1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.85 mg/mL (16.79 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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