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YK11

Catalog No. T7358 CAS 1370003-76-1

YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity.

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YK11, CAS 1370003-76-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 32.00
5 mg	In stock	$ 50.00
10 mg	In stock	$ 80.00
50 mg	In stock	$ 97.00
100 mg	In stock	$ 122.00
500 mg	In stock	$ 297.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 98%

Biological Description

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Description

In vitro

The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. Suggest that the induction of Fst is important for the anabolic effect of YK11[1].

Molecular Weight	430.53
Formula	C25H34O6
CAS No.	1370003-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 64 mg/mL (148.65 mM)

References and Literature

1. Kanno Y , Ota R , Someya K , et al. Selective Androgen Receptor Modulator, YK11, Regulates Myogenic Differentiation of C2C12 Myoblasts by Follistatin Expression[J]. Biological and Pharmaceutical Bulletin, 2013, 36(9):1460-1465. 2. Yatsu T , Kusakabe T , Kato K , et al. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells[J]. Biological and Pharmaceutical Bulletin, 2018, 41(3):394-398.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Osteogenesis Compound Library Bioactive Compounds Library Max Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library NO PAINS Compound Library Transcription Factor-Targeted Compound Library Endocrinology-Hormone Compound Library Nuclear Receptor Compound Library

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Keywords

YK11 1370003-76-1 Endocrinology/Hormones Androgen Receptor YK 11 Inhibitor YK-11 inhibit inhibitor

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