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XL041

Catalog No. T14679 CAS 1256918-39-4

Synonyms: BMS-852927

XL041 (BMS-852927) is an agonist of LXRβ-selective.

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XL041, CAS 1256918-39-4

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5 mg	8-10 weeks	Inquiry
25 mg	8-10 weeks	Inquiry
50 mg	8-10 weeks	Inquiry
100 mg	8-10 weeks	Inquiry
1 mL * 10 mM (in DMSO)	8-10 weeks	Inquiry

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	XL041 (BMS-852927) is an agonist of LXRβ-selective.
In vitro	XL041 (BMS-852927) functions as an LXRβ-selective agonist, exhibiting 20% activity towards LXRα and 88% towards LXRβ relative to a comprehensive pan agonist in transactivation assays. Despite similar binding affinities to LXRα and LXRβ (19 and 12 nM, respectively)[1], XL041 proves to be potent, with an EC50 of 9 nM and achieves 26% activity in an in vitro human whole-blood endogenous target gene activation assay (WBA).
In vivo	XL041 (BMS-852927) exhibits a highly favorable efficacy profile at therapeutic doses in both cynomolgus monkeys and mice. In a distinct study, the compound effectively inhibited the progression of atherosclerosis over a 12-week period in LDLR knockout (KO) mice. Additionally, pre-treating C57BL/6J mice with XL041 for seven days induced a potent and dose-dependent increase in cholesterol efflux, peaking at a 70% enhancement over the control with a dose of 3 mg/kg/day. This effect was also observed in LDLR KO mice. Notably, the dosage range that inhibits atherosclerosis (0.1-3 mg/kg/day) aligns closely with the dosage range that stimulates macrophage reverse cholesterol transport (RCT) (0.03-3 mg/kg/day), indicating a conserved mechanism of action for LXR agonists in mitigating the disease.

Synonyms	BMS-852927
Molecular Weight	609.51
Formula	C29H28Cl2F2N2O4S
CAS No.	1256918-39-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (164.07 mM), Sonification is recommended.

References and Literature

1. Kirchgessner TG, et al. Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils. Cell Metab. 2016 Aug 9;24(2):223-33.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

XL041 1256918-39-4 Metabolism Liver X Receptor BMS852927 BMS-852927 XL-041 XL 041 BMS 852927 inhibitor inhibit

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