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Topilutamide

Name: Topilutamide
Brand: TargetMol
SKU: T13184
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13184Cas No. 260980-89-0

Alias Fluridil, BP766

Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.

Topilutamide

🥰Excellent

Purity: 99.24%

Catalog No. T13184Alias Fluridil, BP766Cas No. 260980-89-0

Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.

Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$198	In Stock
25 mg	$413	In Stock
50 mg	$648	In Stock
100 mg	$923	In Stock
200 mg	$1,260	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.24%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Topilutamide (Fluridil) is a topical nonsteroidal antiandrogen.
In vivo	One of the commonly used approaches to treat metastatic prostate cancer is via first-generation nonsteroidal anti-androgens (NSAAs), namely Flutamide, Nilutamide, Bicalutamide and Topilutamide[1].
Synonyms	Fluridil, BP766

Chemical Properties

Molecular Weight	403.23
Formula	C₁₃H₁₁F₆N₃O₅
Cas No.	260980-89-0
Smiles	CC(O)(CNC(=O)C(F)(F)F)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
Relative Density.	1.588 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (632.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4800 mL	12.3999 mL	24.7997 mL	123.9987 mL
5 mM	0.4960 mL	2.4800 mL	4.9599 mL	24.7997 mL
10 mM	0.2480 mL	1.2400 mL	2.4800 mL	12.3999 mL
20 mM	0.1240 mL	0.6200 mL	1.2400 mL	6.1999 mL
50 mM	0.0496 mL	0.2480 mL	0.4960 mL	2.4800 mL
100 mM	0.0248 mL	0.1240 mL	0.2480 mL	1.2400 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc