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TD-5471 hydrochloride

Catalog No. T13106 CAS 530084-35-6

TD-5471 hydrochloride is a selective and potent long-acting human β2-adrenergic receptor agonist for the treatment of chronic obstructive pulmonary disease (COPD).

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TD-5471 hydrochloride Chemical Structure

TD-5471 hydrochloride, CAS 530084-35-6

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 700.00
5 mg	In stock	$ 1,800.00

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Purity: 99.57%

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Description	TD-5471 hydrochloride is a selective and potent long-acting human β2-adrenergic receptor agonist for the treatment of chronic obstructive pulmonary disease (COPD).
Targets&IC50	guinea pig trachea:8.7 (pEC50)
In vitro	In an in vitro guinea pig trachea model, TD-5471 exhibits potent activity with a slow onset. Its potency is evident, as indicated by a pEC50 of 8.7 in the guinea pig tracheal ring assay. Notably, TD-5471 is structurally distinct from Milveterol, and its prolonged duration of action aligns with a correlation observed in other long-acting β2-agonist discovery programs, specifically related to hydrophobicity[1].
In vivo	In an in vivo guinea pig model of bronchoprotection, TD-5471 demonstrates a prolonged and dose-dependent duration of action. The efficacy of TD-5471 is notably high, as evidenced by its excellent potency measured 1.5 hours after nebulized dosing. To ensure suitability for once-daily dosing in humans, a 72-hour time point is chosen, considering that a high dose of Salmeterol (300 μg/mL) provides bronchoprotection lasting ≥24 hours in this model. At the 72-hour time point, TD-5471-mediated bronchoprotection remains dose-dependent and significantly surpasses the efficacy of Salmeterol at nebulizer concentrations of ≥30 μg/mL[1].

Molecular Weight	558.07
Formula	C32H32ClN3O4
CAS No.	530084-35-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jacobsen JR, et al. Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2625-30.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library

Related Products

Related compounds with same targets

Picumeterol Dipivefrin hydrochloride Noradrenaline bitartrate Arbutamine Pafenolol Trifluoperazine Tulobuterol hydrochloride Faxeladol

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Keywords

TD-5471 hydrochloride 530084-35-6 GPCR/G Protein Neuroscience Adrenergic Receptor TD5471 hydrochloride TD5471 Hydrochloride TD 5471 hydrochloride TD 5471 Hydrochloride TD-5471 Hydrochloride inhibitor inhibit

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