Powder: -20°C for 3 years
In solvent: -80°C for 2 years
T56-LIMKi is a selective inhibitor of LIMK2.
Description | T56-LIMKi is a selective inhibitor of LIMK2. |
Targets&IC50 | LIMK2:35.2 μM. |
In vitro | T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and accordingly inhibits the growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma[1]. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1−/−MEFs with an IC50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50 μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers[2]. |
In vivo | T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) display a significant decrease in tumor volume than controls[1]. |
Cell Research | T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control[1]. |
Synonyms | T5601640 |
Molecular Weight | 389.334 |
Formula | C19H14F3N3O3 |
CAS No. | 924473-59-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 36 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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T56-LIMKi 924473-59-6 细胞周期 LIM Kinase T-56-LIMKi T56LIMKi inhibit T 5601640 T5601640 LIM Kinase (LIMK) LIMKs T-5601640 Inhibitor T56 LIMKi inhibitor