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T56-LIMKi

Catalog No. T3960   CAS 924473-59-6
Synonyms: T5601640

T56-LIMKi is a selective inhibitor of LIMK2.

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T56-LIMKi, CAS 924473-59-6
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description T56-LIMKi is a selective inhibitor of LIMK2.
Targets&IC50 LIMK2:35.2 μM.
In vitro T56-LIMKi efficiently inhibits the growth of ST88-14, U87, Panc-1 cells, A549 lung cancer cells with IC50 values of 18.3, 7.4, 35.2 and 90 μM, respectively. T56-LIMKi decreases phosphorylated cofilin (p-cofilin) levels and accordingly inhibits the growth of several cancerous cell lines, including those of pancreatic cancer, glioma and schwannoma[1]. It blocks the phosphorylation of cofilin which leads to actin severance and inhibition of tumor cell migration, tumor cell growth, and anchorage-independent colony formation in soft agar. T56-LIMKi (10-50 μM) reduces p-cofilin in a dose-dependent manner in NF1−/−MEFs with an IC50 of 30 μM. Notably, the inhibitor does not affect the amounts of total cofil. 50 μM T56-LIMKi causes a statistically significant reduction in the number of cells exhibiting stress fibers[2].
In vivo T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) display a significant decrease in tumor volume than controls[1].
Cell Research T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control[1].
Synonyms T5601640
Molecular Weight 389.334
Formula C19H14F3N3O3
CAS No. 924473-59-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 36 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Rak R, et al. Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model. Oncoscience. 2014 Jan 1;1(1):39-48. eCollection 2014. 2. Mashiach-Farkash E, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Inhibitor Library DNA Damage & Repair Compound Library Cell Cycle Compound Library Fluorochemical Library Kinase Inhibitor Library Target-Focused Phenotypic Screening Library Anti-Aging Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
TH-257 BMS-3 BMS-5 T56-LIMKi LIMK-IN-22j LY2812223 LX7101 R-10015

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Keywords

T56-LIMKi 924473-59-6 细胞周期 LIM Kinase T-56-LIMKi T56LIMKi inhibit T 5601640 T5601640 LIM Kinase (LIMK) LIMKs T-5601640 Inhibitor T56 LIMKi inhibitor