Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects
Description | Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects |
In vivo | Substance P 1-7, SP(1-7), which is the main SP fragment in rat CNS, was injected intranigrally. SP(1-7) was found to act as a very potent antagonist against the SP-induced responses and was formed locally in the nigra after SP injection. It is proposed that SP(1-7) is an endogenous modulator of SP actions. Generation of peptide fragments, which retain receptor affinity but not efficacy, may be a general mechanism for autoregulation in peptidergic systems[1]. |
Synonyms | Substance P 1-7 |
Molecular Weight | 900.04 |
Formula | C41H65N13O10 |
CAS No. | 68060-49-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Substance P(1-7) 68060-49-1 GPCR/G Protein Neuroscience Others Neurokinin receptor Substance P 1-7 Substance P(1 7) Inhibitor Tachykinin receptor inhibit NK receptor Neurokinin Receptor Substance P(17) inhibitor