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Substance P(1-7)

Catalog No. T7396 CAS 68060-49-1

Synonyms: Substance P 1-7

Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

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Substance P(1-7), CAS 68060-49-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Substance P 1-7 is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

In vivo

Substance P 1-7, SP(1-7), which is the main SP fragment in rat CNS, was injected intranigrally. SP(1-7) was found to act as a very potent antagonist against the SP-induced responses and was formed locally in the nigra after SP injection. It is proposed that SP(1-7) is an endogenous modulator of SP actions. Generation of peptide fragments, which retain receptor affinity but not efficacy, may be a general mechanism for autoregulation in peptidergic systems[1].

Synonyms	Substance P 1-7
Molecular Weight	900.04
Formula	C41H65N13O10
CAS No.	68060-49-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Herrera-Marschitz M , Terenius L , Sakurada T , et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain[J]. Brain Research, 1990, 521(1-2):316-320. 2. Skogh A , Lesniak A , Gaugaz F Z , et al. Impact of N -methylation of the substance P 1–7 amide on anti-allodynic effect in mice after peripheral administration[J]. European Journal of Pharmaceutical Sciences, 2017, 109.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Substance P(1-7) 68060-49-1 GPCR/G Protein Neuroscience Others Neurokinin receptor Substance P 1-7 Substance P(1 7) Inhibitor Tachykinin receptor inhibit NK receptor Neurokinin Receptor Substance P(17) inhibitor

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