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Stepronin

Catalog No. T21433 CAS 72324-18-6

Synonyms: Prostenoglycine, Tiofacic, Tiase, TTPG

Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Stepronin, CAS 72324-18-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 538.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 99.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Stepronin (TTPG) shows expectorant activities and inhibits airway secretion.
In vitro	In canine tracheal epithelium, Stepronin (0.1-100 µM) dose-dependently reduces Isoproterenol-evoked short circuit current value, the basal secretion and Isoproterenol-evoked potential difference value[1]. In submucosal glands, Stepronin (100 µM) causes the potent inhibition of Isoproterenol-induced [3H]-glycoconjugate secretion[3].

Synonyms	Prostenoglycine, Tiofacic, Tiase, TTPG
Molecular Weight	273.33
Formula	C10H11NO4S2
CAS No.	72324-18-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (823.2 mM)

H2O: Insoluble

References and Literature

1. de Giorgi L, Habeshaw JA, Broadhurst K, Carminati P, Oxford JS. Anti-human immunodeficiency virus activity of a new immunosuppressant drug called stepronin. Transplant Proc. 1999 Dec;31(8):3257. PubMed PMID: 10616467. 2. Romano A, Di Fonso M, Mormile F, Quaratino D, Giuffreda F, Venuti A. Accelerated cell-mediated broncho-obstructive reaction to inhaled stepronin: a case report. Allergy. 1996 Apr;51(4):269-71. PubMed PMID: 8792926. 3. Yamada K, et al. An expectorant, stepronin, reduces airway secretion in vitro. Respiration. 1994;61(1):42-7. 4. de Giorgi L, Arrigoni-Martelli E, Matossian-Rogers A. Immunosuppressive effect of stepronin (TS-5010680) in mice. Transplant Proc. 1994 Dec;26(6):3513-6. PubMed PMID: 7998255.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Stepronin 72324-18-6 Others Prostenoglycine Tiofacic Tiase TTPG inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.