Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 289.00 | |
1 mg | 35 days | $ 289.00 | |
5 mg | 35 days | $ 708.00 |
Description | Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which causes down-regulation of MYC transcription. |
In vitro | Stauprimide (10 μM; 6 hours) inhibits MYC transcription in the majority of cell lines tested (EC50: range of 30 nM-8 μM). It also decreases MYC levels between 15% to over 90%. Stauprimide (5 μM; 3 hours) suppresses MYC Transcription by decreasing NME2 Nuclear Translocation. Stauprimide (2-8 μM; 24-72 hours) down-regulates MYC leads to the inhibition of cell proliferation in vitro (IC50: 780 nM in RXF 393 cells). Stauprimide (4-10 μM; 6 hours) acts with different EC50s and with different degrees of maximal MYC mRNA down-regulation in different cell lines [1]. |
In vivo | Stauprimide (p.o.; 50 mg/kg; once daily; 30 days, 55 days) blocks tumor growth, decreases MYC protein levels in xenograft mouse with RXF 393 or CAKI-1 cells. It also inhibits MYC transcription in the RXF 393 tumor [1]. |
Molecular Weight | 584.62 |
Formula | C35H28N4O5 |
CAS No. | 154589-96-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Stauprimide 154589-96-5 Others inhibitor inhibit