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Spathulenol

Spathulenol
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Spathulenol

Catalog No. TN2233Cas No. 6750-60-3
Spathulenol is a natural ingredient from Aristolochia yunnanensis that has anti-inflammatory, antioxidant, anti-proliferation, anti-ulcer and anti-mycobacterium activities. Spathulenol showed significant antioxidant activity in DPPH system with IC50 of 85.60 μg/mL.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$158In Stock
2 mg$237In Stock
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Product Introduction

Bioactivity
Description
Spathulenol is a natural ingredient from Aristolochia yunnanensis that has anti-inflammatory, antioxidant, anti-proliferation, anti-ulcer and anti-mycobacterium activities. Spathulenol showed significant antioxidant activity in DPPH system with IC50 of 85.60 μg/mL.
In vitro
In the DPPH and MDA systems, spathulenol demonstrates high antioxidant activity. It shows significant DPPH free radical activity, with IC50 values of 85.60 μg/mL[1].
In vivo
Spathulenol, when administered orally at a dose of 300 mg/kg, demonstrates significant inhibition in the mice paw edema and pleurisy model induced by Cg[1].
In a spontaneous lipoperoxidation model using rat brain homogenate, when incubated under controlled temperature and oxygenation conditions, PG-1 exhibits high activity with an IC50 value of 26.13 μg/mL. This activity is comparable to that of the commercial antioxidant BHT (38.41 μg/mL). Consequently, PG-1 contributes to a reduction in the generation of malondialdehyde (MDA), a toxic product resulting from the degradation of cell membranes through lipid peroxidation. This reduction in MDA levels helps prevent cell ruptures and mutations[1].
Chemical Properties
Molecular Weight220.35
FormulaC15H24O
Cas No.6750-60-3
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 90 mg/mL (408.44 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.5382 mL22.6912 mL45.3823 mL226.9117 mL
5 mM0.9076 mL4.5382 mL9.0765 mL45.3823 mL
10 mM0.4538 mL2.2691 mL4.5382 mL22.6912 mL
20 mM0.2269 mL1.1346 mL2.2691 mL11.3456 mL
50 mM0.0908 mL0.4538 mL0.9076 mL4.5382 mL
100 mM0.0454 mL0.2269 mL0.4538 mL2.2691 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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