Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 726.00 | |
50 mg | 6-8 weeks | $ 943.00 | |
100 mg | 6-8 weeks | $ 1,420.00 |
Description | Ro 28-1675 is an effective allosteric GK activator (IC50: 0.24± 0.0019 uM). |
Targets&IC50 | GK:54 nM (EC50) |
In vitro | Ro 28-1675 (50 mg/Kg; p.o.;) treatment to male C57B1/6J mice caused a statistically significant reduction in fasting glucose levels and improvement in glucose tolerance relative to the vehicle-treated animals. Glucokinase activator The R stereoisomer Ro 28-1675 activated GK with an SC1.5 of 0.24 uM, while the S isomer did not activate GK up to 10 uM. A comparison of rat PK parameters indicated that Ro 28-1675 displayed lower clearance and higher oral bioavailability compared to 9a. Ro 28-1675 reduced fasting and postprandial glucose levels following an OGTT following a single oral dose, was well tolerated and displayed no adverse effects related to drug administration other than hypoglycemia at the maximum dose (400 mg) [1] |
Synonyms | Ro 28-1675 |
Molecular Weight | 378.51 |
Formula | C18H22N2O3S2 |
CAS No. | 300353-13-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (132.10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RO-28-1675 300353-13-3 Others RO281675 Ro 28-1675 RO 28 1675 inhibitor inhibit