Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 106.00 | |
5 mg | Inquiry | $ 282.00 | |
10 mg | Inquiry | $ 468.00 | |
25 mg | Inquiry | $ 747.00 | |
1 mL * 10 mM (in DMSO) | Inquiry | $ 533.00 |
Description | Q-VD-OPh (quinolyl-valyl-O-methylaspartyl-[-2,6-difluorophenoxy]-methyl ketone) is a broad-spectrum caspase inhibitor, provides a cost-effective, non-toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. |
In vitro | It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk. Q-VD-OPh is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase 12. In addition to the increased effectiveness, Q-VD-OPh was not toxic to cells, even at high concentrations. Q-VD-OPh is equally effective at inhibiting the three major apoptotic pathways, it can inhibit recombinant caspases 1, 3, 8, and 9 with IC50 values ranging from 25 to 400 nM2. The effectiveness of Q-VD-OPh as an apoptotic inhibitor is evidenced by the complete suppression of an apoptotic inducer capable of inducing substantial cell death in less than 4 hours. Q-VD-OPh protected against the substantial apoptosis induced by actinomycin D. In addition, Q-VD-OPh alone exhibited little or no toxicity, even at extremely high concentrations [2]. |
Molecular Weight | 527 |
Formula | C26H25F2N3O6 |
CAS No. | 402592-44-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: ≥97.4 mg/mL
H2O: <1 mg/mL
DMSO: ≥26.35mg/mL
You can also refer to dose conversion for different animals. More
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Q-VD(OMe)-OPh 402592-44-3 Others QVD(OMe)OPh Q VD(OMe) OPh inhibitor inhibit