Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 346.00 | |
50 mg | In stock | $ 516.00 | |
100 mg | In stock | $ 736.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM). |
Targets&IC50 | Porcupine:0.5 Nm |
In vitro | Porcupine, an enzyme, facilitates the attachment of palmitoleate to a serine residue within Wnt proteins, essential for their secretion. Porcupine-IN-1 exhibits potency comparable to the clinical compound LGK974 in a cell-based STF reporter gene assay and effectively inhibits the secretion of Wnt3A, thereby confirming its role as a porcupine inhibitor[1]. |
In vivo | Porcupine-IN-1 exhibits moderate metabolic clearance in human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg), while demonstrating high clearance rates in mouse liver microsomes (109 mL/min/kg)[1]. |
Cell Research | HEK293T cells are transfected with pLinbin-Wnt3A plasmid or vehicle control. The HEK293T cells are then treated with or without compounds (Porcupine-IN-1). Western Blot is used after 48 h to analyze both the cell lysis and culture medium[1]. |
Synonyms | Porcupine-IN-1 |
Molecular Weight | 410.44 |
Formula | C25H19FN4O |
CAS No. | 2036044-77-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (243.64 mM)
You can also refer to dose conversion for different animals. More
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Porcn-IN-1 2036044-77-4 Stem Cells Porcupine inhibit PorcnIN1 Inhibitor Porcupine-IN-1 Porcn IN 1 inhibitor