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Phox-I2

Catalog No. T25952 CAS 353495-22-4

Synonyms: Phox I2, PhoxI2

Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Phox-I2, CAS 353495-22-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 248.00
10 mg	In stock	$ 358.00
25 mg	In stock	$ 589.00
50 mg	In stock	$ 839.00
100 mg	In stock	$ 1,160.00
500 mg	In stock	$ 2,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 243.00

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Purity: 99.52%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Phox-I2 is an NOX2-specific inhibitor. Phox-I2 reverts ROS-accumulation and leads to refusion of mitochondrial networks.

Synonyms	Phox I2, PhoxI2
Molecular Weight	337.33
Formula	C18H15N3O4
CAS No.	353495-22-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.8 mg/mL (14.23 mM)

References and Literature

1. Hagenbuchner J, et al. Very long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery. Sci Rep. 2018 Feb 19;8(1):3254. 2. Mortadza SS, Sim JA, Stacey M, Jiang LH. Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells. Sci Rep. 2017 Mar 21;7:45032.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Phox-I2 353495-22-4 Immunology/Inflammation NADPH-oxidase Phox I2 PhoxI2 Phox-I-2 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.